This large shrine is in Cannaregio alongside the enormous Scuola Nova della Misericordia, near a former abbey and the deconsecrated church of Santa Maria Valverde. It’s really more of a tabernacle than a shrine; it even has a marble prayer step where worshippers can kneel.
I hope to stroll by this one someday and see that they have cleaned the carvings on the base. These reliefs show the Madonna della Misericordia in the center, protecting two worshippers under her cloak, with a Venetian merchant ship on either side of her.
The wrought iron gate protecting this shrine is quite lovely but makes it challenging to photograph the image inside of a rather Byzantine-looking painting of the Blessed Virgin Mary and Child. This sacred image is relatively new because for centuries, the tabernacle housed a 14th century Gothic statue of the Pieta which was stolen in 1973. Story goes that the thief lost the statue when he fell into a canal while making his escape, but that might just be an urban legend. The book I Capitelli di Venezia has a photo of the lost statue that I scanned in.
Many thanks to Bert! After I posted this, he sent this wonderful photo below of the image inside and notes, "I love the way the Child's right hand has circled His Mother's neck. It's not right anatomically, but it still looks good." I agree!