I have stayed in Venice three times (as well as once in Venice Mestre). The first time, I stayed in the Rialto sestiere (neighborhood), the second time in the Santa Croce sestiere, and the third time in the Cannaregio sestiere. Santa Croce was my favorite sestiere.
Campo San Giacomo dell'Orio, a very cool place to hang out:
La Zucca ~ my very favorite place to eat in Venice, also located in the Santa Croce sestiere.
Two more photos taken nearby Campo San Giacomo dell'Orio soon after I arrived in Venice in 2006: